MIND4-17
CAS No. : 345989-24-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $120 | In-stock |
| 10mg | $180 | In-stock |
| 25mg | $325 | In-stock |
| 50mg | $487 | In-stock |
| 100mg | $731 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-121523 |
| M.Wt: | 405.43 |
| Formula: | C20H15N5O3S |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
MIND4-17 is a potent NRF2 activator that covalently modifies a C151 residue of Keap1. MIND4-17 disrupts Keap1-Nrf2 association, leading to Nrf2 protein stabilization and nuclear translocation. MIND4‐17 exerts potent antioxidant activity[1][2].
In Vitro:MIND4-17 (0.1-2 μM; 24 hr) significantly and concentration-dependently increases the expression of the canonical ARE genes Nqo1, Hmox1, Srx1, and to a lesser degree Gclc[1].
MIND4-17 (0.1-2 μM; 24 hr) shows a concentration-dependent induction of NQO1 and GCLM proteins in both WT and HD mutant ST14A cells[1].
MIN4-17 (0.1-10 μM) reduces ROS levels and nitrogen intermediates production in microglia[1].
In Vivo:MIND4‐17 (2 mg/kg; intravitreal injection; once) activates Nrf2 signaling and attenuates retinal dysfunction by light damage in mice[2].
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