AZD3409
CAS No. : 345915-10-8
(Synonyms: EBP-921)
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| Cat. No. : | HY-10062 |
| M.Wt: | 652.84 |
| Formula: | C34H41FN4O4S2 |
| Purity: | >98 % |
| Solubility: |
AZD3409 is a prenyl inhibitor that exhibits inhibitory activity against both farnesyl transferase and geranylgeranyl transferase I. AZD3409 inhibits the growth of breast cancer cells, with IC50s of 220 nM (MDA-MB-468), 180 nM (MDA-MB-361), and 290 nM (SK-Br-3). AZD3409 significantly reduces the activation level of AKT in breast cancer cell lines. AZD3409 induces G0/G1 phase arrest in MDA-MB-468 cells, causes G2/M phase arrest in MDA-MB-361 cells. AZD3409 can be used for the study of breast cancer[1].
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