D-Mannose
CAS No. : 3458-28-4
| Size | Price | Stock |
|---|---|---|
| 25g | $20 | In-stock |
| 100g | $28 | In-stock |
| 500g | $69 | In-stock |
| 1000g | $138 | In-stock |
| > 2 kg | Get quote | |
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| Cat. No. : | HY-N0379 |
| M.Wt: | 180.16 |
| Formula: | C6H12O6 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic);H2O : ≥ 50 mg/mL |
D-Mannose is a C-2 superpolymer of glucose that occurs naturally in many plants and fruits. D-Mannose has anti-inflammatory and antitumor activity. D-Mannose plays an important role in immune regulation[1][2][3].
In Vitro:D-Mannose (5.5, 11, 25 mM, 24 h) inhibits macrophage activation by inhibiting the production of IL-1β[1].
D-Mannose (25 mM, 24-72 h) stimulates Treg cell differentiation in human and mouse cells by promoting TGF-β activation and inhibiting immunopathology[2].
In Vivo:D-Mannose (2g/kg, intraperitoneally injected 6 times per hour, killed 3 h later) can protect mice from DSS-induced ulcerative colitis [1].
D-Mannose (1.1 M D-mannose dissolved in water for 2 months) alleviates bone loss in mice through Treg cell proliferation and intestinal microbiome-dependent anti-inflammatory effects[3].
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