BCX-1898
CAS No. : 345267-14-3
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| Cat. No. : | HY-105395 |
| M.Wt: | 340.46 |
| Formula: | C17H32N4O3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
BCX-1898, a cyclopentane derivative, is an orally active and selective influenza virus neuraminidase inhibitor. BCX-1898 has antiviral activity with EC50s of <0.01-21 μM on influenza A (H1N1, H3N2, and H5N1) and influenza B viruses replication in MDCK cells. BCX-1898 shows protection against the mouse influenza model[1][2].
In Vivo:BCX-1898 (1, 10 mg/kg/day; Oral; 22 days) shows complete protection against the influenza virus with 10 mg/kg/day[2].
BCX-1898 (0.01, 0.1 mg/kg/day; intranasal treatment; 20 days) demonstrates complete protection (10 out of 10 survived)[2].
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