2-Oleoylglycerol
CAS No. : 3443-84-3
(Synonyms: 2-OG)
| Size | Price | Stock |
|---|---|---|
| 28 mM * 500 μL in Ethanol | $170 | In-stock |
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| Cat. No. : | HY-W011121 |
| M.Wt: | 356.55 |
| Formula: | C21H40O4 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
2-Oleoylglycerol (2-OG) is a lipid found in the diet. It is a GPR119 agonist, with an EC50 value of 2.5 μM in activating hGPR119 in transiently transfected COS-7 cells. 2-Oleoylglycerol enhances the inflammatory response of macrophages and promotes fibrosis by activating the GPR119/TAK1/NF-κB/TGF-β1 signaling pathway. It also stimulates glucagon-like peptide 1 (GLP-1) secretion in vivo. 2-Oleoylglycerol is expected to be used in the research of non-alcoholic steatohepatitis (NASH) [1][2][3]. IC50 & Target:IC50: 2.5 μM (hGPR119) (in COS-7 cells)[1] In Vitro: 2-Oleoylglycerol (50 μg/mL, 24 hours) activates RAW264.7 cells via the GPR119/TAK1/NF-κB/TGF-β1 signaling pathway[3]. In Vivo: 2-Oleoylglycerol (20 μg/mouse in 0.2 mL PBS, i.v., three times a week for 6 weeks) induces liver fibrosis in a non-alcoholic steatohepatitis (NASH) model through promoting TGF-β1 production in liver MΦs[3].
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