Levalbuterol
CAS No. : 34391-04-3
(Synonyms: (R)-Albuterol; (R)-Salbutamol; Levosalbutamol)
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| Cat. No. : | HY-B1675 |
| M.Wt: | 239.31 |
| Formula: | C13H21NO3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Levalbuterol ((R)-Albuterol; (R)-Salbutamol) is a short-acting?β2-adrenergic receptor agonist and the active (R)-enantiomer of Salbutamol. Levalbuterol is a more potent bronchodilator than Salbutamol and has the potential for the treatment of COPD[1]. In Vitro: Levalbuterol (10 μM; 24 hours) induces 11β-HSD1 mRNA expression, however, it does not influence 11β-HSD2expression in airway epithelial cells[1].Levalbuterol (10 μM; 24 hours) significantly reduces both LPS- and TNF-α-induced NF-κB activity while increasing GRE activation in an 11β-HSD1 dependent manner in a transformed mouse airway epithelial cell line[1]. In Vivo: Levalbuterol (subcutaneous injection; 1 mg/kg; 14 days) significantly decreases pulmonary inflammation in OVA mice, demonstrated a decrease in eosinophilia and IgE[3].
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