PET-16
CAS No. : 34387-64-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $120 | Get quote |
| 10mg | $195 | Get quote |
| 25mg | $390 | Get quote |
| 50mg | $620 | Get quote |
| 100mg | $980 | Get quote |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-122184 |
| M.Wt: | 443.31 |
| Formula: | C26H20BrP |
| Purity: | >98 % |
| Solubility: |
PET-16 is a selective HSP70 inhibitor that binds to an allosteric pocket of the substrate-binding domain. PET-16 inhibits the ability of HSP70 to cycle between ATP-bound and ADP-bound states. PET-16 induces apoptosis in multiple myeloma[1].
In Vitro:PET-16 (0.01-100 μM; 72 h) shows cytotoxicity in Multiple myeloma (MM) cell lines with the highest steady-state level of HSP70 showed the lowest IC50[1].
PET-16 (3 μM; 24 h) induces apoptosis in multiple myeloma, along with proteotoxic stress[1].
In Vivo:PET-16 (5-10 mg/kg; i.p.; twice a week; for 3 weeks) markedly decreases p-FAK and BRAF staining in mice[1].
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