Dobutamine
CAS No. : 34368-04-2
| Size | Price | Stock |
|---|---|---|
| 5mg | $40 | In-stock |
| 10mg | $65 | In-stock |
| 25mg | $130 | In-stock |
| 50mg | $208 | In-stock |
| 100mg | $333 | In-stock |
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| Cat. No. : | HY-15746A |
| M.Wt: | 301.38 |
| Formula: | C18H23NO3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Dobutamine is a synthetic catecholamine that acts on α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors). Dobutamine is a selective β1-AR agonist, relatively weak activity at α1-AR and β2-AR. Dobutamine can increase cardiac output and correct hypoperfusion[1][2][3][4].
In Vivo: Dobutamine has a rapid onset of action and a short half-life [2].
Dobutamine (0.15-20 mg/kg; i.p.) results in subsequent increase in the left ventricular function and heart rate acceleration with an increasing dose in wildtype mice[3].
Dobutamine results in significant inotropic, lusitropic, and chronotropic cardiac response with a high dose in wildtype mice[3].
Low doses of Dobutamine significantly increases inotropic and lusitropic cardiac performance without chronotropic changes in the Tgαq*44 mice[3].
Dobutamine increases heart rate only after high doses, but then inotropic and lusitropic cardiac functional reserve is lost[3].
Dobutamine increases alveolar liquid clearance in ventilated rats by beta-2 receptor stimulation[4].
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