AG-7404
CAS No. : 343565-99-1
| Size | Price | Stock |
|---|---|---|
| 1mg | $385 | In-stock |
| 5mg | $1350 | In-stock |
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| 50 mg | Get quote | |
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| Cat. No. : | HY-19476 |
| M.Wt: | 523.54 |
| Formula: | C26H29N5O7 |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic;warming) |
AG-7404 is an orally active, irreversible inhibitor of the picornavirus 3C protease. AG-7404 blocks the processing of viral polyproteins, thereby inhibiting viral replication. AG-7404 has synergistic antiviral activity with capsid inhibitors such as V-073 (HY-104074) or BTA798 (HY-106254) and is effective against V-073-resistant variants. AG-7404 is used in the study of enterovirus infections such as poliovirus[1][2][3].
In Vitro:AG-7404 (0.080-0.674 μM; 3 d) inhibits viral replication in HeLa cells with poliovirus with an EC50 of 0.080-0.674 μM[1].
AG-7404 (0.218-0.819 μM; 3 d) remains active in V-073-resistant poliovirus strains with an EC50 of 0.218-0.819 μM[1].
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