CP-94707

CP-94707 is an HIV-1 reverse transcriptase (HIV-1 reverse transcriptase) inhibitor, with an IC₅₀ of 4 μM against wild-type and HIV-1 reverse transcriptase ^Y181I-Y188L double mutant enzymes, and an IC₅₀ of 10 μM against HIV-1 reverse transcriptase ^K103N mutant enzyme. CP-94707 inhibits the initiation of negative-strand DNA synthesis primed by tRNA^Lys-3, as well as the elongation of DNA synthesis mediated by HIV-1 reverse transcriptase. CP-94707 can be used in studies related to HIV infection^[1]. In Vitro:CP-94,707 (0.10-32 μM; 45 min) inhibits tRNA^Lys-3-primed initiation activity of wild-type HIV-1 RT with an IC₅₀ of 4 μM, retains full activity against Y181I-Y188L double mutant HIV-1 RT (IC₅₀ = 4 μM), and shows only 2.5-fold reduced activity against K103N single mutant HIV-1 RT (IC₅₀ = 10 μM)^[1].
CP-94,707 (0.10-32 μM) inhibits elongation activity of wild-type HIV-1 RT with an IC₅₀ of 4 μM, demonstrating no selectivity for initiation over elongation steps^[1].