Folitixorin
CAS No. : 3432-99-3
(Synonyms: 5,10-Methylenetetrafolate; ANX-510 (free acid))
| Size | Price | Stock |
|---|---|---|
| 1mg | $280 | In-stock |
| 5mg | $785 | In-stock |
| 10mg | $1300 | In-stock |
| 25mg | $2730 | In-stock |
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| Cat. No. : | HY-14769 |
| M.Wt: | 457.44 |
| Formula: | C20H23N7O6 |
| Purity: | >98 % |
| Solubility: | H2O : 5 mg/mL (ultrasonic;warming;heat to 60°C) |
Folitixorin (5,10-Methylenetetrafolate; ANX-510 free acid) is a reduced form of Folic acid (HY-16637) and a cofactor of thymidylate synthase. Folitixorin acts as an essential cofactor to promote the formation of a tight ternary complex between thymidylate synthase and FdUMP, thereby enhancing the inhibitory effect of FdUMP on thymidylate synthase. Folitixorin in combination with 5-fluorouracil and αVEGF reduces tumor volume in colorectal tumor models of nude mice. Folitixorin is used in related research on Yoshida sarcoma, P-388 leukemia, and colorectal cancer[1][2][3]. In Vitro:Folitixorin (1000 ns) forms structurally conserved stable complexes with human thymidylate synthase and Klebsiella pneumoniae thymidylate synthase [2]. In Vivo:Folitixorin (0.6 mg/mouse; i.p.; once daily for five consecutive days) in combination with 5‑Fluorouracil and αVEGF reduces tumor volume and improves survival rate in a colorectal tumor model of nude mice[3].
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