DL-Kynurenine
CAS No. : 343-65-7
| Size | Price | Stock |
|---|---|---|
| 100mg | $68 | In-stock |
| 250mg | $111 | In-stock |
| 1g | $262 | In-stock |
| 5g | $1213 | In-stock |
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| Cat. No. : | HY-W014504 |
| M.Wt: | 208.21 |
| Formula: | C10H12N2O3 |
| Purity: | >98 % |
| Solubility: | 1M HCl : 20 mg/mL (ultrasonic;warming;adjust pH to 1 with HCl;heat to 60°C) |
DL-Kynurenine is a key metabolite in the tryptophan metabolic pathway and can cross the blood-brain barrier. DL-Kynurenine has a bidirectional regulatory effect on neural excitability. DL-Kynurenine can enhance the convulsive and lethal effects caused by strychnine. DL-Kynurenine is the precursor of Kynurenic acid (HY-100806), which is an antagonist at the glycine site of NMDA receptors and can counteract excitatory toxins. DL-Kynurenine can be used for research on neurotoxicity[1][2].
In Vivo:DL-Kynurenine (150-450 mg/kg, i.p., single dose) dose-dependently alleviates the motor behavior deficits caused by Quinolinic acid (HY-100807), and its combined use with Colchicine (HY-16569) can enhance this effect in rats[1].
DL-Kynurenine (0.1-40 μg/mice, 5 μL, i.c.v, single dose) significantly enhances the convulsive effect and mortality rate of Strychnine in mice[2].
DL-Kynurenine (25-100 mg/kg, i.p., single dose) prolongs the convulsive latency period of Strychnine, but does not alter the convulsive threshold[2].
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