Phenopyrazone

Phenopyrazone (Diphenox), a derivative of Antipyrine (HY-B0171), exhibits oral activity as well as analgesic, antipyretic, anti-inflammatory, and antidiarrheal properties. Phenopyrazone can be used in research related to headache, rheumatism, chronic diarrhea and varicose veins^[1][2]. In Vivo: Phenopyrazone (p.o.; single dose; daily for 5 days) alone has minimal analgesic activity against Phenylquinone (HY-W275039)-induced writhing in mice, but significantly potentiates the analgesic activity of aminopyrine when co-administered or via prior daily treatment^[1].
Phenopyrazone (p.o.; single dose) alone has no detectable antipyretic activity against yeast-induced fever in rats at oral doses up to 640 mg/kg^[1].
Phenopyrazone (p.o.) exhibits anti-inflammatory activity against carrageenin-induced hind paw edema in rats with an ED₅₀ of 574.0 mg/kg p.o^[1].
Phenopyrazone (oral administration) serves as a component in preparations for venous disorders and induces pseudo‑lupus syndrome accompanied by high‑titer antimitochondrial antibodies^[2].