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|---|---|---|
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| Cat. No. : | HY-17366R |
| M.Wt: | 342.82 |
| Formula: | C18H19ClN4O |
| Purity: | >98 % |
| Solubility: |
Clozapine N-oxide (Standard) is the analytical standard of Clozapine N-oxide. This product is intended for research and analytical applications. Clozapine N-oxide is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide activates the DREADD receptor hM3Dq and hM4Di. Clozapine N-oxide cannot cross the blood-brain barrier[1][2][3][4]. Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor (EC50=11 nM) agonist[5][6]. IC50 & Target:Human muscarinic designer receptors (DREADDs)[1]
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