Echinatin
CAS No. : 34221-41-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $80 | In-stock |
| 10mg | $140 | In-stock |
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| Cat. No. : | HY-N0269 |
| M.Wt: | 270.28 |
| Formula: | C16H14O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
Echinatin is a chalcone isolated from the Chinese herbal medicine Gancao with hepatoprotective and anti-inflammatory effects[1]. Echinatin can be quickly absorbed and eliminated and extensively distributed with an absolute bioavailability of approximately 6.81% in Rat[2].
In Vitro:Echinatin (0-40 μM, 60 min) inhibits Nigericin induced NLRP3 inflammasome activation by binding to HSP90 and suppressing its ATPase activity in LPS-primed BMDMs[2].
Echinatin (0-40 μM, 1-5 days) induces apoptosis and autophagy, and inhibits cell proliferation, migration, invasion in ESCC (KYSE30 and KYSE270 cells)[4].
In Vivo:Echinatin (20 and 40 mg/kg, i.p.) inhibits LPS-induced septic shock in mice by inhibiting NLRP3 inflammasome activation[2].
Echinatin (20-80 mg/kg, i.p.) shows cardioprotective effect, and relieves I/R-Induced Myocardial Injury in rats[3].
Echinatin (20 and 50 mg/kg, p.o.) inhibits tumor growth and inhibits the AKT/mTOR pathway of KYSE270-derived tumor mice xenografts[4].
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