CAS No. : 34156-56-4
(Synonyms: Trisodium phosphonoformate (hexahydrate); Phosphonoformic acid trisodium salt (hexahydrate))
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| Cat. No. : | HY-W013256 |
| M.Wt: | 300.04 |
| Formula: | CH12Na3O11P |
| Purity: | >98 % |
| Solubility: | H2O : 50 mg/mL (ultrasonic) |
Foscarnet trisodium hexahydrate (Trisodium phosphonatoformate hexahydrate) is a viral DNA polymerase activity inhibitor, leading to reversible suppression of viral replication. Foscarnet trisodium hexahydrate is an antiherpesvirus agent used in cytomegalovirus retinitis[1][2][3].
In Vitro:Foscarnet sodium (Phosphonoformic acid) inhibit the human cytomegalovirus DNA polymerase (UL54) by mimicking the pyrophosphate leaving group of the nucleotide transfer reaction[1].
Foscarnet sodium (Trisodium phosphonoformate) inhibits Influenza A Victoria (IC50=29 μM), Influenza B HK (IC50=61 μM), and Avian myeloblastosis virus (IC50=5-8 μM), HSV-1, several strains (IC50=0.4-3.5 μM)[2].
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