Foscarnet (trisodium hexahydrate)


CAS No. : 34156-56-4

(Synonyms: Trisodium phosphonoformate (hexahydrate); Phosphonoformic acid trisodium salt (hexahydrate))

34156-56-4
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Cat. No. : HY-W013256
M.Wt: 300.04
Formula: CH12Na3O11P
Purity: >98 %
Solubility: H2O : 50 mg/mL (ultrasonic)
Introduction of 34156-56-4 :

Foscarnet trisodium hexahydrate (Trisodium phosphonatoformate hexahydrate) is a viral DNA polymerase activity inhibitor, leading to reversible suppression of viral replication. Foscarnet trisodium hexahydrate is an antiherpesvirus agent used in cytomegalovirus retinitis[1][2][3]. In Vitro:Foscarnet sodium (Phosphonoformic acid) inhibit the human cytomegalovirus DNA polymerase (UL54) by mimicking the pyrophosphate leaving group of the nucleotide transfer reaction[1].
Foscarnet sodium (Trisodium phosphonoformate) inhibits Influenza A Victoria (IC50=29 μM), Influenza B HK (IC50=61 μM), and Avian myeloblastosis virus (IC50=5-8 μM), HSV-1, several strains (IC50=0.4-3.5 μM)[2].

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