Nucleozin
CAS No. : 341001-38-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $74 | In-stock |
| 10mg | $119 | In-stock |
| 25mg | $220 | In-stock |
| 50mg | $350 | In-stock |
| 100mg | $490 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-50001 |
| M.Wt: | 426.85 |
| Formula: | C21H19ClN4O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 20 mg/mL (ultrasonic) |
Nucleozin, a potent inhibitor of influenza A virus infection, induces the formation of nucleoprotein (NP) aggregates and antagonizes its nuclear accumulation, leading to cessation of viral replication. Nucleozin impedes influenza A virus replication in vitro with a nanomolar EC50[1]. In Vitro: Nucleozin inhibits infection of MDCK cells by the viruses influenza A/WSN/33, H3N2 and Vietnam/1194/04 (H5N1) with an EC50 of 0.069 μM, 0.16 μM and 0.33 μM in plaque reduction assay (PRA) , respectively, severely suppresses viral growth at 0.1 μM and totally inhibites virus production at 1 μM in multicycle growth assays[1]. In Vivo: Nucleozin protectes mice challenged with lethal doses of avian influenza A H5N1[1].
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