SMIFH2
CAS No. : 340316-62-3
| Size | Price | Stock |
|---|---|---|
| 1mg | $38 | In-stock |
| 5mg | $80 | In-stock |
| 10mg | $120 | In-stock |
| 50mg | $520 | In-stock |
| 100mg | $890 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-16931 |
| M.Wt: | 377.21 |
| Formula: | C15H9BrN2O3S |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
SMIFH2 is a formin specific inhibitor. SMIFH2 inhibits actin polymerization by Formins and affects the actin cytoskeleton[1].
IC50 & Target: Formin[1]
In Vitro: SMIFH2 (25 uM; 1-16 hours) induces dynamic cytoskeletal remodelling in U2OS cells[1].
SMIFH2 (25 μM) reduces p300, mDia2 and p53 levels in a proteasome-independent manner[1].
SMIFH2 reduces expression and activity of p53 through a post-transcriptional, proteasome-independent mechanism that influences remodelling of the cytoskeleton[1].
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