N-Phthaloyl-L-glutamic acid
CAS No. : 340-90-9
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| Cat. No. : | HY-W011592 |
| M.Wt: | 277.23 |
| Formula: | C13H11NO6 |
| Purity: | >98 % |
| Solubility: |
N-Phthaloyl-L-glutamic acid is an orally active anti-inflammatory agent. N-Phthaloyl-L-glutamic acid inhibits Lipopolysaccharides (HY-D1056) (LPS)-induced nitric oxide production in murine spleen cells. N-Phthaloyl-L-glutamic acid does not exhibit significant cytotoxicity in vitro against tumor cells and BALB/c mice spleen cell culture. N-Phthaloyl-L-glutamic acid can be used for the research of inflammation[1].
In Vitro:N-Phthaloyl-L-glutamic acid (compound 2f) (25-50 μg/mL; 72 h) inhibits Lipopolysaccharides (HY-D1056) (LPS)-induced nitric oxide production and shows low cytotoxicity against spleen cell BALB/c mice[1].
N-Phthaloyl-L-glutamic acid (25 μg/mL; 48 h) exhibits weak antiproliferative activity against MDA/MB-435, HCT-8, and SF-295 cells[1].
In Vivo:N-Phthaloyl-L-glutamic acid (compound 2f) (100 mg/kg; p.o.; single dose) inhibits predominantly neutrophilic leukocytes (PMNL) migration in BALB/c mice (carrageenan-induced air pouch model) (with a PMNL infiltration inhibition of 61.7%)[1].
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