T 162559
CAS No. : 339532-12-6
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| Cat. No. : | HY-105402 |
| M.Wt: | 517.59 |
| Formula: | C20H28FN5O6S2 |
| Purity: | >98 % |
| Solubility: |
T 162559 is a potent and selective inhibitor of the Na+/H+ exchanger isoform NHE1 with IC50 values of 0.96 nM. T 162559 does not affect Na+/HCO3- cotransport and Na+/Ca2+ exchange. T 162559 can be used for the research of cardiovascular disease[1].
In Vitro:T-162559 (10-100 nmol/L, continuous infusion started 10 minutes before the induction of global ischemia) concentration-dependently inhibits the reduction in cardiac contractility, progression of cardiac contracture, and increase in lactate dehydrogenase release after global ischemia and reperfusion[2].
In Vivo:T-162559 (0.03-0.1 mg/kg, i.v., 5 mins before coronary occlusion) significantly inhibits the progression of myocardial infarction induced by left coronary artery occlusion and reperfusion in rabbits[2].
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