Panitumumab
CAS No. : 339177-26-3
(Synonyms: ABX-EGF)
| Size | Price | Stock |
|---|---|---|
| 1mg | $220 | In-stock |
| 5mg | $650 | In-stock |
| 10mg | $1040 | In-stock |
| 25mg | $1880 | In-stock |
| 50mg | $3000 | In-stock |
| 100mg | $4800 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-P99041 |
| M.Wt: | 1000.00 |
| Formula: | N/A |
| Purity: | >98 % |
| Solubility: | H2O |
Panitumumab (ABX-EGF) is a fully human IgG2 anti-EGFR monoclonal antibody with anti-tumor activity. Panitumumab inhibits tumor cell proliferation, survival and angiogenesis. Panitumumab can be used in the research of cancers, such as colon cancer[1][2][4].
IC50 & Target:EGFR
In Vitro:Panitumumab (2 nM-2 μM, 3 h) inhibits ligand-dependent autophosphorylation in EGFR-expressing NCI-H1975 cells, NCI-H1650 cells and CHO cells[3].
Panitumumab (0-200 μg/mL, 48 h) inhibits the proliferation of DLD-1 cells[4].
Panitumumab (80 μg/mL, 24 h) increase beclin-1 (a marker of autophagy) levels in Caco-2 cells and DLD-1 cells[4].
In Vivo:Panitumumab (25-500 μg per mouse, i.p., twice a week) inhibits tumor growth in the xenograft models of NCI-H1975 and NCI-H1650 in mice[3].
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