L-Cycloserine

L-Cycloserine ((S)-4-Amino-3-isoxazolidone) is an oral inhibitor of the enzyme gamma-aminobutyric acid (GABA) transaminase (GABA-t) and branched-chain transaminases in Mycobacterium tuberculosis. L-Cycloserine has anticonvulsant properties and inhibits the synthesis of neurotensin in mouse brains^[1][2][3][4]. In Vitro:L-Cycloserine inhibits the growth of M. tuberculosis, with an MIC of 0.3 μg/mL^[1]. In Vivo:L-Cycloserine (25-50 mg/kg, intraperitoneal injection, single dose) has anticonvulsant effects in mice^[2].
L-Cycloserine (30-100 mg/kg, orally or via intraperitoneal injection, twice daily for 5 days) enhances the inhibitory effect on GABA-T activity in mice and boosts its anticonvulsant effects^[3].
L-Cycloserine (100-150 mg/kg, subcutaneous or intraperitoneal injection, once daily for 1 week) can reduce the brain content of gangliosides by 28% when injected subcutaneously, with no effect on the content of neurogangliosides; intraperitoneal injection leads to decreased levels of gangliosides and cerebrosides^[4].
L-Cycloserine (100 mg/kg, subcutaneous or intraperitoneal injection, single dose) affects the level of inhibition of 3-keto-dihydrosphingosine synthase depending on the method of injection^[4].