Silychristin
CAS No. : 33889-69-9
| Size | Price | Stock |
|---|---|---|
| 1mg | $55 | In-stock |
| 5mg | $88 | In-stock |
| 10mg | $140 | In-stock |
| 25mg | $230 | In-stock |
| 50mg | $322 | In-stock |
| 100mg | $450 | In-stock |
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| Cat. No. : | HY-N0647 |
| M.Wt: | 482.44 |
| Formula: | C25H22O10 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Silychristin is an abundant flavonolignan present in the fruits of Silybum marianum, with antioxidant properties. Silychristin is a potent inhibitor of the thyroid hormone transporter MCT8, and elicits a strong inhibition of T3 uptake with an IC50 of 110 nM[1][2].
IC50 & Target: MCT8[2]
In Vitro: Silychristin exhibits a strong inhibition of MCT8-mediated T3 uptake with an IC50 of 110 nM in MCT8 overexpressing MDCK1-cells[2].
Silychristin causes no cytotoxic for fibroblasts[3].
Silychristin (6.5-75 μM; 24 hours) diminishes UVA toxicity and reduces ROS generation, and the protective effect is dose-dependent[3].
Silychristin (12.5μM, 25μM) reduces the metalloproteinase-1 (MMP-1) level in cells[3].
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