LY456236 (free base)
CAS No. : 338738-57-1
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| Cat. No. : | HY-103566A |
| M.Wt: | 281.31 |
| Formula: | C16H15N3O2 |
| Purity: | >98 % |
| Solubility: |
LY456236 free base is a selective, non-competitive and orally active antagonist of glutamate receptor 1 (mGlu1), which can inhibit phosphatidylinositol hydrolysis with an IC50 of 0.145 μM. LY456236 free base can also inhibit EGFR, with an IC50 of 0.918 μM. LY456236 free base blocks cell proliferation by inhibiting the MAPK pathway, reversing the anti-apoptotic effect of DHPG (HY-12598A). LY456236 free base can be used in epilepsy research[1][3].
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