LY456236
CAS No. : 338736-46-2
| Size | Price | Stock |
|---|---|---|
| 25mg | $181 | In-stock |
| 50mg | $307 | In-stock |
| 100mg | $521 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-103566 |
| M.Wt: | 317.78 |
| Formula: | C16H16ClN3O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 250 mg/mL (ultrasonic;warming;heat to 60°C) |
LY456236 is a selective, non-competitive and orally active antagonist of glutamate receptor 1 (mGlu1), which can inhibit phosphatidylinositol hydrolysis with an IC50 of 0.145 μM. LY456236 can also inhibit EGFR, with an IC50 of 0.918 μM. LY456236 has anticonvulsant effects and blocks cell proliferation by inhibiting the MAPK pathway, reversing the anti-apoptotic effect of DHPG (HY-12598A). LY456236 can be used in epilepsy research[1][2][3]. IC50 & Target:IC50: 0.145 μM (mGlu1), 0.91 μM (EGFR)[1] In Vitro:LY456236 (2 μM; 30 min) reduces DHPG (HY-12598A)-stimulated OCCM-30 proliferation[2]. In Vivo:LY456236 shows anticonvulsant effects in mice (3-100 mg/kg; i.p.; once) and rats (10-60 mg/kg; oral; once)[3].
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