Sabinene

Sabinene is an naturally occurring bicyclic monoterpene which can be used as flavorings, perfume additives, fine chemicals, and advanced biofuels. Sabinene is also an orally active compound to attenuates skeletal muscle atrophy and regulates ROS-mediated MAPK/MuRF-1 pathways^[1][2]. In Vitro: Sabinene (10-300 μM; 18 h) induces predominant recovery of reductions of myotube diameters under starvation^[2].
Sabinene (300 μM; 18 h) diminishes the elevated E3 ubiquitin ligase muscle ring-finger protein-1 (MuRF-1) expression and p38 mitogen-activated protein kinase (MAPK), and attenuates extracellular signal-regulated kinase1/2 (ERK1/2) phosphorylations in starved myotubes^[2].
Sabinene (300 μM; 18 h) decreases the increased level of reactive oxygen species (ROS) in myotubes under starvation^[2].
In Vivo: Sabinene (6.4 mg/kg; p.o.; once daily; during the fasting for 2 d) attenuates skeletal muscle atrophy by regulating the activation mechanism of ROS-mediated MAPK/MuRF-1 pathways in starved myotubes, probably leading to the reverse of reduced muscle fiber size in fasted rats^[2].