Uridine 5'-monophosphate (disodium salt)

Uridine 5'-monophosphate (5'-Uridylic acid) disodium salt is an orally active mitochondrial ATP-dependent potassium channel activator that has a protective effect on the heart. Uridine 5'-monophosphate disodium salt can promote the synthesis of CDP-choline and induce apoptosis in intestinal epithelial cells, which is beneficial for gut development and reduces diarrhea^[1][2][3]. In Vitro:Uridine 5'-monophosphate (10 mM; 6 h) disodium salt promotes late apoptosis in pig intestinal epithelial cells IPEC-J2^[1]. In Vivo:Uridine 5'-monophosphate (476 mg; oral; daily; 10 days) disodium salt promotes apoptosis and renewal of intestinal villus tip epithelial cells in pigs, which benefits gut development and reduces the rate of diarrhea^[1].
Uridine 5'-monophosphate (0.02-1 mmol/kg; i.g.; single dose) disodium salt can enhance the synthesis of CDP-choline in the brains of gerbils^[2].
Uridine 5'-monophosphate (30 mg/kg; i.v.; single dose) disodium salt has protective properties for the heart in rats, preventing ischemic injury and some arrhythmias^[3].