ICA
CAS No. : 3374-88-7
(Synonyms: N-[4-(2-Pyridinyl)-2-thiazolyl]-2-pyridinamine)
| Size | Price | Stock |
|---|---|---|
| 5mg | $360 | In-stock |
| 10mg | $540 | In-stock |
| 50mg | $1200 | In-stock |
| 100mg | $1680 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-22044 |
| M.Wt: | 254.31 |
| Formula: | C13H10N4S |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 49.5 mg/mL |
ICA (N-(pyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine) is a SK channel inhibitor that has antileishmanial activity with an IC50 of 2.1 µM. IC50 & Target: IC50: 2.1 µM (Antileishmanial)[1] In Vitro: The SK channel inhibitor ICA exhibits antiarrhythmic effects. ICA prevents electrically induced runs of atrial fibrillation in the isolated right atrium and induces atrial postrepolarization refractoriness and depolarizes resting membrane potential. ICA at 1 to 10 μM slows conduction velocity. At increased pacing frequencies, SK channel inhibition by ICA (10-30 μM) demonstrates prominent depression of other sodium channel-dependent parameters[2].
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