Necrostatin-5
CAS No. : 337349-54-9
(Synonyms: Nec-5)
| Size | Price | Stock |
|---|---|---|
| 5mg | $50 | In-stock |
| 10mg | $80 | In-stock |
| 25mg | $180 | In-stock |
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| Cat. No. : | HY-124546 |
| M.Wt: | 383.49 |
| Formula: | C19H17N3O2S2 |
| Purity: | >98 % |
| Solubility: | DMSO : 5 mg/mL (ultrasonic;warming;heat to 60°C) |
Necrostatin-5 (Nec-5) is a potent necroptosis inhibitor with an EC50 value of 0.24 µM. Necrostatin-5 also is a RIP1 inhibitor. Necrostatin-5 shows cardioprotective effects[1][2][3].
In Vitro:Necrostatin-5 (1, 5, 10, 50, 100 µM) inhibits LDH release in a dose-dependent mnner[3].
Necrostatin-5 (100 µM) protects MH-S cells against challenge with S. aureus, Listeria monocytogenes, S. pneumoniae, uropathogenic Escherichia coli (UPEC), and protectes against pneumolysin-induced death[3].
In Vivo:Necrostatin-5 (2.46 mg/kg; i.p.) shows cardioprotective effects on the isolated heart model in rats[2].
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