R116031
CAS No. : 336884-84-5
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| Cat. No. : | HY-123497 |
| M.Wt: | 660.69 |
| Formula: | C35H38F6N4O2 |
| Purity: | >98 % |
| Solubility: |
R116031 is a selective Neurokinin-1 (NK-1) receptor antagonist with a Ki of 0.45 nM for human NK-1 receptor. R116031 inhibits Substance P (HY-P0201)-induced peripheral effects (skin reactions and plasma extravasation in guinea pigs) and a central effect (thumping in gerbils).R116031 labeled with 3H significantly accumulate in the striatum, olfactory tubercule, olfactory bulb and locus coeruleus in gerbils models. R116031 can be used as a positron emission tomography (PET) ligand for PET imaging[1].
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