Benzolamide
CAS No. : 3368-13-6
(Synonyms: CL11366)
| Size | Price | Stock |
|---|---|---|
| 5mg | $60 | In-stock |
| 10mg | $100 | In-stock |
| 25mg | $200 | In-stock |
| 50mg | $300 | In-stock |
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| 200 mg | Get quote | |
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| Cat. No. : | HY-118467 |
| M.Wt: | 320.37 |
| Formula: | C8H8N4O4S3 |
| Purity: | >98 % |
| Solubility: | DMSO : 250 mg/mL (ultrasonic) |
Benzolamide (CL11366) is a potent carbonic anhydrase (CA) inhibitor, with Kis of 15 nM, 9 nM, 94 nM and 78 nM for hCA I, hCA II, EcoCAγ and VchCAγ, respectively. Benzolamide also inhibits CAS3, with a Ki of 54 nM. Benzolamide can be used for the research of glaucoma and seizures[1][2][3].
IC50 & Target: Ki: 15 nM (hCA I), 9 nM (hCA II), 94 nM (EcoCAγ), 78 nM (VchCAγ), 54 nM (CAS3)[1][2]
In Vitro: Benzolamide inhibits hCA I, hCA II, EcoCAγ and VchCAγ, with Kis of 15 nM, 9 nM, 94 nM and 78 nM, respectively[1].
Benzolamide shows selectivity for CAS3 (Ki=54 nM) over CAS1 (Ki=2115 nM) and CAS2 (Ki=410 nM)[2].
In Vivo: Benzolamide (90 µmol/kg; i.p.) decreases brain pH and suppresses electrographic post-asphyxia seizures in rats[3].
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