Hypophyllanthin
CAS No. : 33676-00-5
| Size | Price | Stock |
|---|---|---|
| 1mg | $60 | In-stock |
| 5mg | $170 | In-stock |
| 10mg | $280 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-N4108 |
| M.Wt: | 430.49 |
| Formula: | C24H30O7 |
| Purity: | >98 % |
| Solubility: | DMSO : 33.33 mg/mL (ultrasonic) |
Hypophyllanthin is a major lignan in Phyllanthus spp, with strong anti-inflammatory activity. Hypophyllanthin directly inhibits P-glycoprotein (P-gp) activity and did not interfere with multidrug resistance protein 2 (MRP2) activity[1][2].
IC50 & Target: P-gp[2]
In Vitro: Hypophyllanthin down-regulates COX-2, TNF-α, and IL-1β gene expressions in U937 macrophages by interfering with the activation of NF-κB, MAPKs, and Akt[1].
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