Vestipitant
CAS No. : 334476-46-9
(Synonyms: GW597599)
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| Cat. No. : | HY-12140 |
| M.Wt: | 491.44 |
| Formula: | C23H24F7N3O |
| Purity: | >98 % |
| Solubility: |
Vestipitant (GW597599) is a neurokinin-1 receptor antagonist (pKi: 9.4, hNK1) with hypnotic effects and the ability to suppress primary insomnia. Vestipitant can effectively block substance P-mediated extracellular regulated kinase phosphorylation and relieve anxiety and possible depression induced by the agonist GR73632 (HY-P1192) in gerbils. Vestipitant can also improve functional dyspnea, anxiety, insomnia, irritable bowel disease, gastroesophageal reflux disease, tinnitus and antiemetic effects[1][2][3].
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