1,4-Butanediamine (dihydrochloride)
CAS No. : 333-93-7
(Synonyms: Putrescine (dihydrochloride); NSC 60545 (dihydrochloride); Putramine (dihydrochloride))
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| Cat. No. : | HY-Y1781 |
| M.Wt: | 161.07 |
| Formula: | C4H14Cl2N2 |
| Purity: | >98 % |
| Solubility: | DMSO : 10 mg/mL (ultrasonic);H2O : 50 mg/mL (ultrasonic) |
1,4-Diaminobutane dihydrochloride is an endogenous metabolite, acts as an indicator of pollution-induced stress in higher plants: barley and rape stressed with Cr(III) or Cr(VI). 1,4-Diaminobutane dihydrochloride as an important source of GABA.1,4-Diaminobutane dihydrochloride has antidepressant and analgesic activity[1][2].
IC50 & Target:Human Endogenous Metabolite[1]
In Vitro:1,4-Butanediamine (100-1000 μM, 24 h) dihydrochloride stimulates cell proliferation in CT-26 colon tumor cells[3].
1,4-Butanediamine (0-50 mM, 2 h) dihydrochloride reduces antibiotic (polymyxin B (HY-149179))-induced oxidative stress in Burkholderia cenocepacia[4].
In Vivo:1,4-Butanediamine (200-400 mg/k, i.p.) dihydrochloride shows analgesic activity in rats[5].
1,4-Butanediamine (1–10 mg/kg, i.p.) dihydrochloride shows antidepressant-like effects in mice (forced swimming test and tail suspension test)[6].
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