STOCK2S-26016


CAS No. : 332922-63-1

332922-63-1
Price and Availability of CAS No. : 332922-63-1
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5mg $328 In-stock
10mg $525 In-stock
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Cat. No. : HY-112143
M.Wt: 333.38
Formula: C20H19N3O2
Purity: >98 %
Solubility: 10 mM in DMSO
Introduction of 332922-63-1 :

STOCK2S-26016 is a WNK signalling inhibitors. STOCK2S-26016 inhibits WNK4 and WNK1 with IC50s of 16 μM and 34.4 μM, respectively. STOCK2S-26016 has potential for antihypertensive research[1]. IC50 & Target:IC50: 16 μM (WNK4); 34.4 μM (WNK1)[1] In Vitro: STOCK2S-26016 (10 and 30 minutes) blocks the effect of L-NAME on phosphorylated sodium-chloride cotransporter (NCC) in mDCT cells[2].
STOCK2S-26016 (25-200 μM) drastically and dose-dependently reduces the phosphorylation of STE20/SPS1-related proline/alanine-rich protein kinase (SPAK) and NCC in mpkDCT cells[1].
STOCK2S-26016 (50-200 μM) drastically and dose-dependently reduces the phosphorylation of SPAK and Na/K/Cl cotransporter 1 (NKCC1) in MOVAS cells[1].

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