Abatacept (powder)
CAS No. : 332348-12-6
(Synonyms: CTLA4lg (powder); BMS-188667 (powder); Orencia)
| Size | Price | Stock |
|---|---|---|
| 1mg | $480 | In-stock |
| 5mg | $880 | In-stock |
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| Cat. No. : | HY-108829A |
| M.Wt: | 1000.00 |
| Formula: | N/A |
| Purity: | >98 % |
| Solubility: |
Abatacept (CTLA4lg; BMS-188667) powder is a soluble fusion protein consisting of the extra-cellular domain of human CTLA4 and a fragment of the Fc portion of human IgG1 (hinge and CH2 and 3 domains). Abatacept powder is a selective T-cell co-stimulation modulator and a protein agent for the autoimmune diseases[1][2][3].
In Vivo: Abatacept (powder) reduces paw edema, and the SC Multiple-dose group shows significantly greater (tobs = 2.50) paw edema reduction compared with the IV dose group[2].
Abatacept (powder) exhibits linear PK across the studied doses. The NCA clearance (CL) is 20.8 mL/day/kg, volume (Vss) is 146 mL/kg, and bioavailability (F) of the SC dose dosing is 57.7%[2].
Abatacept (powder) (oral; 10 mg/kg; every 2 days) reduces the proportion of activated T cells (CD44highCD62L–) and inhibits the up-regulation of ICOS and CD71 in homozygous DO11.10 RAG-2–/– BALB/c (H-2d/d) mice[3].
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