Chromeceptin
CAS No. : 331859-86-0
(Synonyms: 94G6)
| Size | Price | Stock |
|---|---|---|
| 5mg | $90 | In-stock |
| 10mg | $140 | In-stock |
| 25mg | $290 | In-stock |
| 50mg | $420 | In-stock |
| 100mg | $650 | In-stock |
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| Cat. No. : | HY-115449 |
| M.Wt: | 359.35 |
| Formula: | C19H16F3N3O |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic);H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) |
Chromeceptin (94G6) is an IGF signaling pathway inhibitor. Chromeceptin suppresses IGF2 expression at mRNA and protein levels in hepatocyte and HCC cells. Chromeceptin inhibits the phosphorylation levels of AKT and mTOR[1].
In Vitro: Chromeceptin (94G6) (5 µM) inhibits IGF2 expression in Hep3B-derived TS cells in a time-dependent manner[1].
Chromeceptin decreases the Phosphorylation levels of protein kinase B (AKT, Ser463) and rapamycin (mTOR, Ser 2481 and Ser 2448) in TS cells[1].
Chromeceptin represses the phosphorylation at ser371 in mTOR effectors ribosomal protein S6 kinase (p70S6K)[1].
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