ζ-Stat
CAS No. : 3316-02-7
(Synonyms: NSC37044)
| Size | Price | Stock |
|---|---|---|
| 5mg | $360 | In-stock |
| 10mg | $570 | In-stock |
| 50mg | $1700 | In-stock |
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| Cat. No. : | HY-123979 |
| M.Wt: | 384.36 |
| Formula: | C10H8O10S3 |
| Purity: | >98 % |
| Solubility: | H2O : 62.5 mg/mL (ultrasonic) |
ζ-Stat (NSC37044) is a specific and atypical PKC-ζ inhibitor, with an IC50 of 5 μM. ζ-Stat can reduce melanoma cell lines proliferation and induce apoptosis, and has antitumor activity in vitro[1][2].
IC50 & Target: IC50: 5 μM (PKC-ζ)[1]
In Vitro: ζ-Stat (0.1-20 µM) shows only 13% inhibition on PKC-ι at 20 μM, but shows a significant inhibition on PKC-ζ as 51% at 5 μM level[1].
ζ-Stat (0.1-10 µM; 3 d) significantly decreases cell proliferation of SK-MEL-2 and MeWo upon increasing the concentrations[1].
ζ-Stat (7 or 10 µM; 24-72 h) and 5-FU in combination is able to decrease the viability of LoVo CRC cells by more than 75%[2].
ζ-Stat (5 µM; 3 d) shows a significant diminution of phosphorylated, total PKC-ζ, Bcl-2 and PARP levels, and increases Caspase-3 and cleaved-PARP levels in SK-MEL-2 and MeWo cells[1].
ζ-Stat (5 µM; 1-10 h) does not show significant cytotoxicity on MEL-F-NEO, SK-MEL-2 and MeWo cells[1].
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