LG101506
CAS No. : 331248-11-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $925 | Get quote |
| 10mg | $1385 | Get quote |
| 25mg | $2500 | Get quote |
| 50mg | $4000 | Get quote |
| 100mg | $6300 | Get quote |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-108524 |
| M.Wt: | 420.53 |
| Formula: | C25H34F2O3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
LG101506 is a selective and orally active RXR modulator with a Ki of 2.7 nM for RXRα. LG101506 can be used for the research of type 2 diabetes and cancer[1][2].
IC50 & Target:Ki: 2.7 nM (RXRα)[1]
In Vitro:LG101506 synergizes with BRL 49653 (HY-17386) to enhance activation at the RXR/PPARγ heterodimer with an EC50 of 3.1 nM[1].
LG101506 (15.6-1000 nM) blocks the production of NO in a dose-dependent manner in RAW264.7 stimulated with LPS (HY-D1056) for 24 hours[2].
LG101506 (100-1000 nM; 24 h) inhibits inflammatory pathways induced by LPS (HY-D1056) or TNFα in RAW264.7 cells[2].
LG101506 (30 and 100 nM; 1-24 h) induces differentiation in U937 leukemia cells[2].
In Vivo:LG101506 (10 mg/kg; in diet for 16 weeks) suppresses lung carcinogenesis in A/J mice[2].
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