MRT-10
CAS No. : 330829-30-6
| Size | Price | Stock |
|---|---|---|
| 1mg | $40 | In-stock |
| 5mg | $100 | In-stock |
| 10mg | $166 | In-stock |
| 25mg | $371 | In-stock |
| 50mg | $540 | In-stock |
| 100mg | $775 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-108507 |
| M.Wt: | 465.52 |
| Formula: | C24H23N3O5S |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
MRT-10 is a seven-transmembrane receptor smoothened (Smo) antagonist with an IC50 of 0.65 μM in the micromolar range in various Hedgehog (Hh) assays. MRT-10 binds to the Smo receptor at the level of the Bodipycyclopamine binding site. MRT-10 can be used for the research of cancer[1][2].
In Vitro: MRT-10 inhibits the Smo-induced IP accumulation in a dosedependent manner (IC50=2.5 μM) in HEK293 cells[1].
MRT-10 (10-9-10-5 M; 2 h) blocks Bodipy-cyclopamine (5 nM; 2 h) binding to cells expressing mouse Smo in a dosedependent manner with an IC50=0.5 μM[1].
MRT-10 (10-9-10-5 M; 40 h) inhibits ShhN signaling in Shh-light2 cells in a dose-dependent manner with an IC50=0.64 μM[1].
MRT-10 (10-9-10-5 M; 6 days) inhibits the SAG-induced (0.1 μM) alkaline phosphatase (AP) activity with an IC50=0.90 μM ) in C3H10T1/2 cells[1].
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