Peramivir
CAS No. : 330600-85-6
(Synonyms: RWJ-270201; BCX-1812)
| Size | Price | Stock |
|---|---|---|
| 5mg | $80 | In-stock |
| 10mg | $130 | In-stock |
| 25mg | $250 | In-stock |
| 50mg | $400 | In-stock |
| 100mg | $560 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-17015A |
| M.Wt: | 328.41 |
| Formula: | C15H28N4O4 |
| Purity: | >98 % |
| Solubility: | DMSO : < 1 mg/mL (ultrasonic;warming;heat to 60°C) |
Peramivir is an novel cyclopentane neuraminidase inhibitor of influenza virus. Peramivir has antiviral activity and anti-cytokines stom effects. Peramivir can be used for the research of COVID-19[1][2][3].
IC50 & Target:IC50：0.9-4.3 nM (NA)[2]
In Vitro:Peramivir (0.3125-40 μM, 4 h) has nontoxicity to macrophage[1].
Peramivir (2-10 μM, 6-12 h) inhibits cytokine release in LPS-induced hPBMCs[1].
In Vivo:Peramivir (20-60 mg/kg, Intraperitoneal injection, single dose) inhibits LPS-induced cytokine storm, attenuates acute lung injury and prolongs the survival in cytokine storm syndrome model mice[1].
Peramivir (75 mg/kg, Intramuscular injection, once a day for 7 days) rescued BALB scid mice from lethal challenge with BR/08 in immunocompromised murine models of infuenza B virus infection[2].
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