PTP Inhibitor IV
CAS No. : 329317-98-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $80 | In-stock |
| 10mg | $130 | In-stock |
| 25mg | $280 | In-stock |
| 50mg | $450 | In-stock |
| 100mg | $720 | In-stock |
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| Cat. No. : | HY-112478 |
| M.Wt: | 608.62 |
| Formula: | C26H26F6N2O4S2 |
| Purity: | >98 % |
| Solubility: | DMSO : 250 mg/mL (ultrasonic) |
PTP Inhibitor IV is a protein tyrosine phosphatase (PTP) inhibitor that competitively inhibits DUSP14 phosphatase activity with an 50 of 5.21 μM[1]. PTP Inhibitor IV inhibits SHP-2, PTP1B, PTP-ε, PTP Meg-2, PTP-σ, PTP-β, and PTP-μ with 50s of 1.8 μM, 2.5 μM, 8.4 μM, 13 μM, 20 μM, 6.4 μM, and 6.7 μM, respectively[2].
IC50 & Target:IC50: 1.8 μM (SHP-2), 2.5 μM (PTP1B), 8.4 μM (PTP-ε), 13 μM (PTP Meg-2), 20 μM (PTP-σ), 6.4 μM (PTP-β), and 6.7 μM (PTP-μ)[2]; 5.21 μM (DUSP14)[1]
In Vitro: PTP Inhibitor IV down-regulates the catalytic activity of DUSP14 by binding in the catalytic site[1].
PTP Inhibitor IV (0-100 μM; 3 hours) effectively and specifically inhibits DUSP14-mediated dephosphorylation of JNK[1].
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