AX20017
CAS No. : 329221-38-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $84 | In-stock |
| 10mg | $120 | In-stock |
| 25mg | $252 | In-stock |
| 50mg | $432 | In-stock |
| 100 mg | Get quote | |
| 200 mg | Get quote | |
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| Cat. No. : | HY-14987 |
| M.Wt: | 264.34 |
| Formula: | C13H16N2O2S |
| Purity: | >98 % |
| Solubility: | DMSO : 130 mg/mL (ultrasonic) |
AX20017 is a small-molecule protein kinase G (PknG) inhibitor with an IC50 of 0.39 μM. IC50 & Target: IC50: 0.39 μM (PknG)[1] In Vitro: The compound AX20017 inhibitor is bound deep within a narrow pocket formed by the inter lobe cleft of the PknG domain. The main chain Glu233:O and Val235:NH of PknG form hydrogen bonds with AX20017[2].AX20017 results in mycobacterial transfer to lysosomes and killing of the mycobacteria. AX20017 does not affect the human kinases, whereas the activity of PknG is effectively inhibited. AX20017 does not affect cellular morphology, membrane ruffling, or macropinocytosis[3].
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