Withanolide A
CAS No. : 32911-62-9
| Size | Price | Stock |
|---|---|---|
| 1mg | $110 | In-stock |
| 5mg | $280 | In-stock |
| 10mg | $450 | In-stock |
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| Cat. No. : | HY-N7028 |
| M.Wt: | 470.60 |
| Formula: | C28H38O6 |
| Purity: | >98 % |
| Solubility: | DMSO : 10 mg/mL (ultrasonic) |
Withanolide A is an orally active extract from the Indian herb Ashwagandha. Withanolide A can induce apoptosis. Withanolide A has anti-inflammatory and antitumor activity. Withanolide A can be used in the study of neurodegenerative diseases[1][2][3][4].
In Vitro: Withanolide A (1 μM, 4 days) can induce presynaptic and postsynaptic reconstruction of rat neurons and induce significant regeneration of axons and dendrites[1].
Withanolide A (0.5-2 μM, 24-48 h) inhibits growth of CaOV3 and SKOV3 ovarian cancer cells by targeting Notch1 and Notch3[2].
Withanolide A (0.5-50 μg/mL, 3 h) has the potential of vascular relaxation by promoting the production of NO in endothelial cells[3].
In Vivo: Withanolide A (10 μmol/kg, dissolved in 0.5% acacia solution for 21 days orally) prevents neurodegeneration in rats by modulating hippocampal glutathione biosynthesis[4].
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