BRD7116
CAS No. : 329059-55-4
| Size | Price | Stock |
|---|---|---|
| 10mg | $40 | In-stock |
| 25mg | $80 | In-stock |
| 50mg | $130 | In-stock |
| 100mg | $220 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-18714 |
| M.Wt: | 496.66 |
| Formula: | C28H36N2O4S |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 48 mg/mL |
BRD7116 is a cell-non-autonomous inhibitor of leukemic stem cells (LSCs). BRD7116, without directly contacting LSCs, can inhibit LSCs merely by altering the microenvironment. BRD7116 also has any cell-autonomous effects on LSCs and induces transcriptional changes consistent with myeloid differentiation. BRD7116 can be used for the study of leukemia[1].
In Vitro:BRD7116 (0.0625-16 μM) shows activity against LSCes (the LSC-enriched fraction of cells) (EC50 = 200 nM) and patient-derived, primary human leukemia cells, and displays limited activity against normal hematopoietic stem and progenitor cells (HSPCs) and AML cell lines[1].
BRD7116 (0-15 μM, 3 d) pretreatment of the stroma preferentially inhibits the LSCe cells compared to HSPCs[1].
BRD7116 (5 μM, 6 h) induced transcriptional changes consistent with myeloid differentiation in LSCes[1].
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