inS3-54A18
CAS No. : 328998-53-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $120 | In-stock |
| 10mg | $190 | In-stock |
| 25mg | $330 | In-stock |
| 50mg | $480 | In-stock |
| 100mg | $680 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-103128 |
| M.Wt: | 373.83 |
| Formula: | C23H16ClNO2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
inS3-54A18 is a potent STAT3 inhibitor, with anti-cancer properties. In Vitro: inS3-54A18 (5?μM) reduces wound healing to 64% and 76% for A549 and MDA-MB-231 cells, respectively. inS3-54A18 at 10?μM further reduces the healing to 47% and 39%, respectively. inS3-54A18 inhibits the expression of STAT3 downstream target genes and the binding of STAT3 to its endogenous target sequences. inS3-54A18 does not affect the constitutive or IL-6-induced STAT3 activation (Tyr705 phosphorylation) but represses STAT3 target gene (survivin) expression[1]. In Vivo: inS3-54A18 (200?mg/kg, p.o.) inhibits tumor growth, metastasis and expression of STAT3 target genes in a mouse xenograft model of A549 cells[1].
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