4E1RCat
CAS No. : 328998-25-0
| Size | Price | Stock |
|---|---|---|
| 5mg | $88 | In-stock |
| 10mg | $121 | In-stock |
| 25mg | $195 | In-stock |
| 50mg | $275 | In-stock |
| 100mg | $495 | In-stock |
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| Cat. No. : | HY-14427 |
| M.Wt: | 478.45 |
| Formula: | C28H18N2O6 |
| Purity: | >98 % |
| Solubility: | DMSO : 18.33 mg/mL (ultrasonic) |
4E1RCat is an inhibitor of cap-dependent translation, and inhibits eIF4E:eIF4GI interaction, with an IC50 an of ∼4 μM. IC50 & Target: IC50: ∼4 μM (eIF4E/eIF4G)[1] In Vitro: 4E1RCat is an inhibitor of eIF4E:eIF4GI interaction, with an IC50 an of ∼4 μM. 4E1RCat binding to eIF4E also interferes with eIF4G and 4E-BP binding. 4E1RCat inhibits ribosome recruitment to mRNA in a cap-dependent manner[1]. 4E1RCat blocks the capped mRNA translation, and the translation is activated by CDK1/CYCB1. Nearly all new protein synthesis in both mitosis and interphase is cap-dependent and -sensitive to 4E1RCat treatment, in HeLa and U2OS cells[2]. In Vivo: 4E1RCat (15 mg/kg, i.p.) affacts chemosensitivity of Pten+/-Eμ-Myc tumors in mice. 4E1RCat (15 mg/kg, i.p.) sensitizes Pten+/-Eμ-Myc and Tsc2+/-Eμ-Myc lymphomas to the cytotoxic effects of doxorubicin (Dxr), and 4E1RCat targets translation in mice[1].
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