DNMDP
CAS No. : 328104-79-6
| Size | Price | Stock |
|---|---|---|
| 5mg | $150 | In-stock |
| 10mg | $220 | In-stock |
| 25mg | $450 | In-stock |
| 50mg | $720 | In-stock |
| 100mg | $1150 | In-stock |
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| Cat. No. : | HY-W028690 |
| M.Wt: | 304.34 |
| Formula: | C15H20N4O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
DNMDP, a phosphodiesterase 3A (PDE3A) inhibitor, is a potent and selective cancer cell cytotoxic agent. DNMDP binding to PDE3A promotes an interaction between PDE3A and Schlafen 12 (SLFN12). DNMDP shows clear cell-selective cytotoxicity[1].
In Vitro: DNMDP (0-1000 μM; 48 hours) shows clear cell-selective cytotoxicity[1].
HeLa cells undergo apoptosis upon DNMDP treatment, indicates by caspase activity detected by a caspase-sensitive luciferase assay and by poly ADP ribose polymerase (PARP) cleavage. At a concentration of 100 nM, DNMDP specifically inhibits both PDE3A and PDE3B, weakly inhibits PDE10, and had little or no detectable effect on other phosphodiesterases[1].
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