MT477
CAS No. : 328069-91-6
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| Cat. No. : | HY-122241 |
| M.Wt: | 718.77 |
| Formula: | C31H30N2O12S3 |
| Purity: | >98 % |
| Solubility: |
MT477 is a potent protein kinase C (PKC) inhibitor. MT477 induces apoptosis and necrosis. MT477 decreases the protein expression of Ras-GTP, p-Erk1/2, p-Elk1. MT477 shows antitumor activity[1].
In Vitro:MT477 (0.05 mM; 1, 24 h) induces apoptosis and necrosis in a time-dependent manner[1].
MT477 (0.05 mM; 0.5, 1, 2, 4 h) decreases the protein expression of Ras-GTP, p-Erk1/2, p-Elk1 in a time-dependent manner[1].
In Vivo:MT477 (33, 100, 1000 µg/kg; i.p.; once a day on days 1, 4, 8, 16, 18, 20) shows antitumor activity[1].
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