VLX600
CAS No. : 327031-55-0
| Size | Price | Stock |
|---|---|---|
| 5mg | $61 | In-stock |
| 10mg | $99 | In-stock |
| 25mg | $209 | In-stock |
| 50mg | $352 | In-stock |
| 100mg | $605 | In-stock |
| 250mg | $1210 | In-stock |
| 500 mg | Get quote | |
| 1 g | Get quote | |
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| Cat. No. : | HY-12406 |
| M.Wt: | 317.35 |
| Formula: | C17H15N7 |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic) |
VLX600 is an iron-chelating inhibitor of oxidative phosphorylation (OXPHOS). VLX600 causes mitochondrial dysfunction and induces a strong shift to glycolysis. VLX600 displays selective cytotoxic activity against malignant cell and induces autophagy. Anticancer activity[1][2].
In Vitro: VLX600 (6?μM; 72 hours) induces an autophagic response[2].
VLX600 is cytotoxic to HCT116 spheroids. VLX600 induces a HIF-1α-dependent glycolytic response. VLX600 inhibits oxygen consumption in HCT116 cells. VLX600 inhibits phosphorylation of the mTOR downstream effectors 4EBP1 and p70-S6K by an HIF-1α-independent mechanism. VLX600 preferentially leads to decreased ATP levels in cancer but not normal cells[2].
In Vivo: VLX600 (16?mg/kg; i.v.; every third day for 16 days) shows anti-tumor activity in human tumor xenografts[2].
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